2001-2009

Improving outcomes after surgery

Grocott MP

BMJ. 2009 Dec 10;339:b5173. PMID: 20008005
http://www.ncbi.nlm.nih.gov/pubmed/20008005



Patient-related risk factors for postoperative adverse events

Moonesinghe SR, Mythen MG, Grocott MP.

Curr Opin Crit Care. 2009 Aug;15(4):320-7.
doi: 10.1097/MCC.0b013e32832e067c. PMID: 19512920
http://www.ncbi.nlm.nih.gov/pubmed/19512920



Quality of reporting in randomized trials published in high-quality surgical journals

Sinha S, Sinha S, Ashby E, Jayaram R, Grocott MP.

J Am Coll Surg. 2009 Nov;209(5):565-571.e1.
doi: 10.1016/j.jamcollsurg.2009.07.019. PMID: 19854395
http://www.ncbi.nlm.nih.gov/pubmed/19854395



Postoperative gastrointestinal tract dysfunction: an overview of causes and management strategies

Mythen MG.

Cleve Clin J Med. 2009 Nov;76 Suppl 4:S66-71.
doi: 10.3949/ccjm.76.s4.11. PMID: 19880839
http://www.ncbi.nlm.nih.gov/pubmed/19880839



Dehydration induced by bowel preparation in older adults does not result in cognitive dysfunction

Ackland GL, Harrington J, Downie P, Holding JW, Singh-Ranger D, Griva K, Mythen MG, Newman SP.

Anesth Analg. 2008 Mar;106(3):924-9
doi: 10.1213/ane.0b013e3181615247. PMID: 18292441
http://www.ncbi.nlm.nih.gov/pubmed/18292441



Outcome measures for orthopaedic interventions on the hip

Ashby E, Grocott MP, Haddad FS.

J Bone Joint Surg Br. 2008 May;90(5):545-9.
doi: 10.1302/0301-620X.90B5.19746. PMID: 18450615
http://www.ncbi.nlm.nih.gov/pubmed/18450615

The Postoperative Morbidity Survey was validated and used to describe morbidity after major surgery

Grocott MP, Browne JP, Van der Meulen J, Matejowsky C, Mutch M, Hamilton MA, Levett DZ, Emberton M, Haddad FS, Mythen MG.

J Clin Epidemiol. 2007 Sep;60(9):919-28.
PMID: 17689808
http://www.ncbi.nlm.nih.gov/pubmed/17689808



ASA scores in the preoperative patient: feedback to clinicians can improve data quality

Grocott MP, Levett DZ, Matejowsky C, Emberton M, Mythen MG.

J Eval Clin Pract. 2007 Apr;13(2):318-9.
PMID: 17378882
http://www.ncbi.nlm.nih.gov/pubmed/17378882



Pre-operative high sensitivity C-reactive protein and postoperative outcome in patients undergoing elective orthopaedic surgery

Ackland GL, Scollay JM, Parks RW, de Beaux I, Mythen MG.

Anaesthesia. 2007 Sep;62(9):888-94.
PMID: 17697214
http://www.ncbi.nlm.nih.gov/pubmed/17697214



Doppler cardiac output monitoring: a tool for all physicians

Usher SM, Walker DA, Mythen MG.

Br J Hosp Med (Lond). 2007 Mar;68(3):126-30.
PMID: 17419459
http://www.ncbi.nlm.nih.gov/pubmed/17419459



Therapeutic hypothermia after cardiac arrest

Macdonald N, Moonesinghe SR.

Br J Hosp Med (Lond). 2007 Jul;68(7):397.
PMID: 17663323
http://www.ncbi.nlm.nih.gov/pubmed/17663323



Etomidate vs thiopentone for rapid sequence induction in critically ill patients

Moonesinghe SR.

Br J Hosp Med (Lond). 2006 Oct;67(10):556.
PMID: 17069141
http://www.ncbi.nlm.nih.gov/pubmed/17069141



Calcium supplementation of saline-based colloids does not produce equivalent coagulation profiles to similarly balanced salt preparations

Roche AM, James MF, Bennett-Guerrero E, Mythen MG.

J Cardiothorac Vasc Anesth. 2006 Dec;20(6):807-11.
PMID: 17138085
http://www.ncbi.nlm.nih.gov/pubmed/17138085



A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids

Roche AM, James MF, Bennett-Guerrero E, Mythen MG.

Anesth Analg. 2006 Apr;102(4):1274-9.
PMID: 16551936
http://www.ncbi.nlm.nih.gov/pubmed/16551936



Less is not more: a lack of evidence for intraoperative fluid restriction improving outcome after major elective gastrointestinal surgery

Hamilton MA, Mythen MG, Ackland GL.

Anesth Analg. 2006 Mar;102(3):970-1; author reply 971.
PMID: 16492869
http://www.ncbi.nlm.nih.gov/pubmed/16492869



Just scratching the surface: varied coagulation effects of polymer containers on TEG variables

Roche AM, James MF, Grocott MP, Mythen MG.

Eur J Anaesthesiol. 2006 Jan;23(1):45-9.
PMID: 16390565
http://www.ncbi.nlm.nih.gov/pubmed/16390565



Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers

Stephens RC, O'Malley CM, Frumento RJ, Mythen MG, Bennett-Guerrero E.

J Endotoxin Res. 2005;11(4):207-12.
PMID: 16176656
http://www.ncbi.nlm.nih.gov/pubmed/16176656



Postoperative gastrointestinal tract dysfunction

Mythen MG.

Anesth Analg. 2005 Jan;100(1):196-204.
PMID: 15616078
http://www.ncbi.nlm.nih.gov/pubmed/15616078



Plasma volume changes associated with two hydroxyethyl starch colloids following acute hypovolaemia in volunteers

James MF, Latoo MY, Mythen MG, Mutch M, Michaelis C, Roche AM, Burdett E.

Anaesthesia. 2004 Aug;59(8):738-42.
PMID: 15270962
http://www.ncbi.nlm.nih.gov/pubmed/15270962



A descriptive study of the variation in baseline levels of antiendotoxin core antibodies between US and UK populations

Down JF, Barclay GR, Bennett-Guerrero E, Hamilton-Davies C, Stephens R, Grocott MP, Mythen MG.

J Endotoxin Res. 2004;10(3):195-6.
PMID: 15198854
http://www.ncbi.nlm.nih.gov/pubmed/15198854



Should perioperative management target oxygen delivery?

Grocott MP, Chaloner E, Mythen MG.

Br J Anaesth. 2004 Apr;92(4):597; author reply 597-8.
PMID: 15065297
http://www.ncbi.nlm.nih.gov/pubmed/15065297



Effects of a new modified balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation

Roche AM, Mythen MG, James MF.

Br J Anaesth. 2004 Jan;92(1):154-5.
PMID: 14665576
http://www.ncbi.nlm.nih.gov/pubmed/14665576



Assessment of preoperative fluid depletion using bioimpedance analysis

Ackland GL, Singh-Ranger D, Fox S, McClaskey B, Down JF, Farrar D, Sivaloganathan M, Mythen MG.

Br J Anaesth. 2004 Jan;92(1):134-6.
PMID: 14665565
http://www.ncbi.nlm.nih.gov/pubmed/14665565



Comparison of P-POSSUM risk-adjusted mortality rates after surgery between patients in the USA and the UK

Bennett-Guerrero E, Hyam JA, Shaefi S, Prytherch DR, Sutton GL, Weaver PC, Mythen MG, Grocott MP, Parides MK.

Br J Surg. 2003 Dec;90(12):1593-8.
PMID: 14648741
http://www.ncbi.nlm.nih.gov/pubmed/14648741



Citrated blood does not reliably reflect fresh whole blood coagulability in trials of in vitro hemodilution

Roche AM, James MF, Grocott MP, Mythen MG.

Anesth Analg. 2003 Jan;96(1):58-61
PMID: 12505923
http://www.ncbi.nlm.nih.gov/pubmed/12505923



Coagulation effects of in vitro serial haemodilution with a balanced electrolyte hetastarch solution compared with a saline-based hetastarch solution and lactated Ringer's solution

Roche AM, James MF, Grocott MP, Mythen MG.

Anaesthesia. 2002 Oct;57(10):950-5.
PMID: 12358952
http://www.ncbi.nlm.nih.gov/pubmed/12358952



A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer's solution, 6% hetastarch in a balanced-saline vehicle, or 6% hetastarch in saline during major surgery

Martin G, Bennett-Guerrero E, Wakeling H, Mythen MG, el-Moalem H, Robertson K, Kucmeroski D, Gan TJ.

J Cardiothorac Vasc Anesth. 2002 Aug;16(4):441-6.
PMID: 12154422
http://www.ncbi.nlm.nih.gov/pubmed/12154422



The effect of hypothermia on calculated values using saline and automated air tonometry

Chapman MV, Woolf RL, Bennett-Guerrero E, Mythen MG.

J Cardiothorac Vasc Anesth. 2002 Jun;16(3):304-7.
PMID: 12073201
http://www.ncbi.nlm.nih.gov/pubmed/12073201



The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass

Welsby IJ, Bennett-Guerrero E, Atwell D, White WD, Newman MF, Smith PK, Mythen MG.

Anesth Analg. 2002 May;94(5):1072-8.
PMID: 11973165
http://www.ncbi.nlm.nih.gov/pubmed/11973165



Tissue factor pathway inhibitor antigen and activity in 96 patients receiving heparin for cardiopulmonary bypass

Adams MJ, Cardigan RA, Marchant WA, Grocott MP, Mythen MG, Mutch M, Purdy G, Mackie IJ, Machin SJ.

J Cardiothorac Vasc Anesth. 2002 Feb;16(1):59-63.
PMID: 11854880
http://www.ncbi.nlm.nih.gov/pubmed/11854880



Preoperative and intraoperative predictors of postoperative morbidity, poor graft function, and early rejection in 190 patients undergoing liver transplantation

Bennett-Guerrero E, Feierman DE, Barclay GR, Parides MK, Sheiner PA, Mythen MG, Levine DM, Parker TS, Carroll SF, White ML, Winfree WJ.

Arch Surg. 2001 Oct;136(10):1177-83.
PMID: 11585512
http://www.ncbi.nlm.nih.gov/pubmed/11585512



The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients

Wilkes NJ, Woolf R, Mutch M, Mallett SV, Peachey T, Stephens R, Mythen MG.

Anesth Analg. 2001 Oct;93(4):811-6.
PMID: 11574338
http://www.ncbi.nlm.nih.gov/pubmed/11574338



Endotoxin-neutralizing capacity of serum from cardiac surgical patients

Bennett-Guerrero E, Barclay GR, Weng PL, Bodian CA, Feierman DE, Vela-Cantos F, Mythen MG.

J Cardiothorac Vasc Anesth. 2001 Aug;15(4):451-4.
PMID: 11505348
http://www.ncbi.nlm.nih.gov/pubmed/11505348



Decreased endotoxin immunity is associated with greater mortality and/or prolonged hospitalization after surgery

Bennett-Guerrero E, Panah MH, Barclay GR, Bodian CA, Winfree WJ, Andres LA, Reich DL, Mythen MG.

Anesthesiology. 2001 Jun;94(6):992-8.
PMID: 11465625
http://www.ncbi.nlm.nih.gov/pubmed/11465625